High mpv and high cholesterol3/25/2023 ![]() ![]() Furthermore, platelet activity recovers with improved glycemic control. In patients with diabetes, MPV was higher compared with the normal glycemic controls in addition, it has been proposed that an increase in MPV may play a role in the micro- and macro-vascular complications related to diabetes. Recently, increased MPV is emerging as an independent risk factor for thromboembolism, stroke, and myocardial infarction. Larger platelets with higher MPV are hemostatically more reactive and produce higher amounts of the prothrombotic factor Thromboxane A2, increasing a propensity to thrombosis. Platelets play an important role in the normal hemostasis the mean platelet volume (MPV) and an accurate measure of the platelet size are considered markers and determinants of platelet function. Individuals with prediabetes are at a high risk of not only developing diabetes but also of adverse cardiovascular events (myocardial infarction, stroke, or cardiovascular death) in the later life. Prediabetes is a preclinical stage in the hyperglycemia continuum where subjects are at increased risk of developing diabetes in the near future. The criteria for determining prediabetes are generally defined as impaired fasting glucose (IFG) levels, impaired glucose tolerance (IGT), or both. ![]() MPV in patients with prediabetes was higher than that in normal subjects, and was positively associated with FPG levels in prediabetic and normal subjects. MPV was independently and positively associated with FPG, not only in prediabetic subjects but also in normal FPG subjects (β = 0.020 and β = 0.006, respectively). MPV in the high-normal glucose group (Q3) was significantly higher than in the low-normal glucose group (Q1). After adjusting for the confounding parameters, MPV of the prediabetic group was higher than that in other groups (P < 0.001 for Q4 vs. Q1, Q2, and Q3 were defined as normal FPG groups and Q4 was defined as prediabetic group. Age, sex, body mass index (BMI), blood pressure, medical history, smoking habits, alcohol intake, lipid profiles, FPG levels, and MPV were evaluated. We retrospectively studied 1876 Japanese subjects who had undergone health checks at Iida Municipal Hospital. The purpose of the present study was to compare MPV in prediabetic and normoglycemic subjects, and to evaluate the relationship between MPV and fasting plasma glucose (FPG) levels in these two groups. However, the relationship between MPV and prediabetes is poorly understood. In diabetic patients, MPV is higher when compared with normal subjects. Mean platelet volume (MPV) can reflect platelet activity, and high MPV is associated with thrombogenic activation and an increased risk of cardiovascular disease. Prediabetes is an independent risk factor for cardiovascular diseases. ![]()
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